So, you've skipped that Angel Room and gone straight for the dark side, eh? Smart choice (sometimes!). Devil Rooms in The Binding of Isaac offer powerful items in exchange for your precious health. But knowing which pacts are worth making is crucial for a successful run.
Key considerations: Red Heart Container loss vs. Soul Heart loss. An item costing red hearts is more punishing, especially early on. Soul Hearts are generally preferred. Also, think about your build! Are you already strong on damage? Maybe utility items like Brimstone or The Pact are less crucial.
Some top-tier picks include Brimstone (massive laser!), Mutant Spider (quad shot!), and Mark of the Beast (damage up + flight!). Beware of less-than-stellar deals like The Nail (situational damage) or even some seemingly good items that don't synergize with your build.
Ultimately, Devil Room item choices are a gamble. Weigh the risks carefully, consider your current situation, and may the RNG gods be ever in your favor!